THE OXOADIPIC ACID DIARIES

123). It is notable that GLS2 is tumorigenic in breast cancer124, and its expression could compensate for lack of Gls in MYC-induced mouse liver tumours40. This suggests that GLS2 could confer resistance to GLS1-distinct inhibitors, including the allosteric inhibitor BPTES or CB-839, which resistance could possibly be hypothetically avoided by the

These findings elevate some questions about the regulation of caspase activation. Why are two cleavage situations necessary to clear away the prodomain? Our information demonstrate that the cleavage at D9 is needed for cleavage at D28. A person doable explanation is that recognition and binding in the D9 web-site orients the prodomain for cleavage